Night at the Museum #1 is just the sort of movie that could have an entertaining sequel. Why? Because the first one never took itself seriously. The second one would have to be completely weird not to be at least as good. Plus, studios are getting better and better at cranking out sequeals that surpass the originals. Granted, NT2 was a bit of a disappointment, but it was still fun to watch. And NatM2 doesn't have nearly the same kind of expectation riding on it. I, for one, am looking forwards to it.
So anyhow, here's an article mentioning an up and coming actress (Amy Adams from Enchanted) that is being cast in an interesting part. There's some other hints as to the plot of #2 as well. Check it out!
And here is the link to the Wikipedia write up...which hints at a possible casting of Reese Witherspoon as well! Hurrah!